Transformations of Manool. Tri- and Tetracyclic Norditerpenoids with in Vitro Activity against Plasmodium falciparum

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• 作者：Albert W. W. van Wyk ; Kevin A. Lobb ; Mino R. Caira ; Heinrich C. Hoppe ; Michael T. Davies-Coleman
• 刊名：Journal of Natural Products
• 出版年：2007
• 出版时间：August 2007
• 年：2007
• 卷：70
• 期：8
• 页码：1253 - 1258
• 全文大小：262K
• 年卷期：v.70,no.8(August 2007)
• ISSN：1520-6025

文摘

The known 17-norisopimar-15-ene-8ages/gifchars/beta2.gif" BORDER=0 ALIGN="middle">,13ages/gifchars/beta2.gif" BORDER=0 ALIGN="middle">-diol (5) and five new semisynthetic norditerpenoids, ethyl 17-norabiet-13(15)-E-en-8ages/gifchars/beta2.gif" BORDER=0 ALIGN="middle">-ol-16-oate (6), ethyl 17-norabiet-13(15)-Z-en-8ages/gifchars/beta2.gif" BORDER=0 ALIGN="middle">-ol-16-oate (7), 17-norpimaran-13ages/gifchars/alpha.gif" BORDER=0>-ethoxy-8,16-olactone(8), 17-norisopimarane-8ages/gifchars/beta2.gif" BORDER=0 ALIGN="middle">,15-diol (9), and 17-norarabiet-13(15)-ene-8ages/gifchars/beta2.gif" BORDER=0 ALIGN="middle">,16-diol (10), were prepared from manool (11).Standard spectroscopic data including X-ray crystal analysis were used to determine the structures of 5-10. All fivecompounds exhibited in vitro antiplasmodial activity against the malarial parasite Plasmodium falciparum at varyingages/entities/mgr.gif">g mL^-1 concentrations.