Palladium-Catalyzed 6-Endo Selective Alkyl-Heck Reactions: Access to 5-Phenyl-1,2,3,6-tetrahydropyridine Derivatives

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• 作者：Xu Dong ; Ying Han ; Fachao Yan ; Qing Liu ; Ping Wang ; Kexun Chen ; Yueyun Li ; Zengdian Zhao ; Yunhui Dong ; Hui Liu
• 刊名：Organic Letters
• 出版年：2016
• 出版时间：August 5, 2016
• 年：2016
• 卷：18
• 期：15
• 页码：3774-3777
• 全文大小：353K
• 年卷期：0
• ISSN：1523-7052

文摘

A new type of palladium-catalyzed 6-endo-selective alkyl-Heck reaction of unactivated alkyl iodides has been described. This strategy provides efficient access to a variety of 5-phenyl-1,2,3,6-tetrahydropyridine derivatives, which are important structural motifs for bioactive molecules. This process displays a broad substrate scope with excellent 6-endo selectivity. Mechanistic investigations reveal that this alkyl-Heck reaction performs via a hybrid palladium-radical process.