文摘
In this Article, the validity of a model derived for crystal growth rates and supersaturation for solids crystallized from solutions of materials containing multiple conformers is evaluated. A simple and straightforward method for determining crystal growth rates using FBRM and FTIR/ATR is utilized, which leads to a large amount of growth rate data from a single experiment. Supersaturation and crystal growth rate obtained experimentally were in good agreement with model predictions. In particular, data indicated that for the system at hand, crystal growth rate is inversely proportional to crystals size. Further, the solute integration coefficient determined from supersaturation measurements can be slightly overestimated due to surface nucleation and/or agglomeration that can result from supersaturation spikes during antisolvent addition. Last, crystal growth data obtained at different temperatures indicated that slow growth rate observed at low temperatures is likely to be due in part to surface poisoning by the wrong conformer.