A Responsive Europium(III) Chelate That Provides a Direct Readout of pH by MRI
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- 作者：Yunkou Wu ; Todd C. Soesbe ; Garry E. Kiefer ; Piyu Zhao ; A. Dean Sherry
- 刊名：Journal of the American Chemical Society
- 出版年：2010
- 出版时间：October 13, 2010
- 年：2010
- 卷：132
- 期：40
- 页码：14002-14003
- 全文大小：152K
- 年卷期：v.132,no.40(October 13, 2010)
- ISSN：1520-5126
文摘
A europium(III) DO3A-tris(amide) complex is reported for imaging pH by MRI using ratiometric chemical exchange saturation transfer (CEST) principles. Deprotonation of a single phenolic proton between pH 6 and 7.6 results in an 5 ppm shift in the water exchange CEST peak that is easily detected by MRI. Collection of two CEST images at two slightly different activation frequencies provides a direct readout of solution pH without the need of a concentration marker.