Design, Synthesis, and Biological Evaluations of Aplyronine A鈥揗ycalolide B Hybrid Compound

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• 作者：Kenichi Kobayashi ; Yusuke Fujii ; Yuichiro Hirayama ; Shinichi Kobayashi ; Ichiro Hayakawa ; Hideo Kigoshi
• 刊名：Organic Letters
• 出版年：2012
• 出版时间：March 2, 2012
• 年：2012
• 卷：14
• 期：5
• 页码：1290-1293
• 全文大小：820K
• 年卷期：v.14,no.5(March 2, 2012)
• ISSN：1523-7052

文摘

A hybrid compound consisting of aplyronine A and mycalolide B was synthesized, and its biological activities were evaluated. The hybrid compound was found to have somewhat more potent actin-depolymerizing activity than aplyronine A. In contrast, the hybrid compound possessed about 1000-fold less cytotoxicity than aplyronine A. These results indicated that there is no direct correlation between actin-depolymerizing activity and cytotoxicity.