Organocatalytic Approach for C(sp3)鈥揌 Bond Arylation, Alkylation, and Amidation of Isochromans under Facile Conditions
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- 作者：Wataru Muramatsu ; Kimihiro Nakano
- 刊名：Organic Letters
- 出版年：2014
- 出版时间：April 4, 2014
- 年：2014
- 卷：16
- 期：7
- 页码：2042-2045
- 全文大小：284K
- 年卷期：v.16,no.7(April 4, 2014)
- ISSN：1523-7052
文摘
A new catalytic approach for the synthesis of isochroman derivatives via direct C(sp3)鈥揌 bond arylation is described. The oxidation reaction with [bis(trifluoroacetoxy)iodo]benzene facilitates the regeneration of 2,3-dichloro-5,6-dicyano-1,4-benzoquinone in the C(sp3)鈥揌 bond arylation of isochroman. The reaction conditions can also be used for alkyl Grignard reagents and amides to afford the corresponding isochroman derivatives.