Nitrogen-Containing Dimeric nor-Multiflorane Triterpene from a Turraea sp.

详细信息    查看全文

• 作者：Vincent E. Rasamison ; L. Harinantenaina Rakotondraibe ; Carla Slebodnick ; Peggy J. Brodie ; Michel Ratsimbason ; Karen TenDyke ; Yongchun Shen ; Lucien M. Randrianjanaka ; David G. I. Kingston
• 刊名：Organic Letters
• 出版年：2014
• 出版时间：May 16, 2014
• 年：2014
• 卷：16
• 期：10
• 页码：2626-2629
• 全文大小：223K
• 年卷期：v.16,no.10(May 16, 2014)
• ISSN：1523-7052

文摘

The new triterpene turranoic acid (1) and the new N-containing nor-triterpene turraenine (2), along with triptocallic acid B (3) and esculentoic acid (4) were isolated from leaves of a Turraea sp. Compounds 1鈥?b>3 showed weak to moderate in vitro antiplasmodial activity against the chloroquine-resistant Plasmodium falciparum strain FCM29. Compound 1 also displayed weak cytotoxic activity against the nonsmall lung cancer cell line H522-T1 with an IC₅₀ value of 16.4 渭M.