Highly Efficient (R-X-R)-Type Carbamates as Molecular Transporters for Cellular Delivery
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- 作者：Kiran M. Patil ; Rangeetha J. Naik ; Rajpal ; Moneesha Fernandes ; Munia Ganguli ; Vaijayanti A. Kumar
- 刊名：The Journal of the American Chemical Society
- 出版年：2012
- 出版时间：May 2, 2012
- 年：2012
- 卷：134
- 期：17
- 页码：7196-7199
- 全文大小：279K
- 年卷期：v.134,no.17(May 2, 2012)
- ISSN：1520-5126
文摘
The (R-X-R) motif-containing arginine-rich peptides are among the most effective cell-penetrating peptides. The replacement of amide linkages in the (R-X-R) motif by carbamate linkages as in (r-ahx-r)4 or (r-ahx-r-r-apr-r)2 increases the efficacy of such oligomers several-fold. Internalization of these oligomers in mammalian cell lines occurs by an energy-independent process. These oligomers show efficient delivery of biologically active plasmid DNA into CHO-K1 cells.