Multifunctional RNA Nanoparticles
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- 作者：Kirill A. Afonin ; Mathias Viard ; Alexey Y. Koyfman ; Angelica N. Martins ; Wojciech K. Kasprzak ; Martin Panigaj ; Ravi Desai ; Arti Santhanam ; Wade W. Grabow ; Luc Jaeger ; Eliahu Heldman ; Jakob Reiser ; Wah Chiu ; Eric O. Freed ; Bruce A. Shapiro
- 刊名：Nano Letters
- 出版年：2014
- 出版时间：October 8, 2014
- 年：2014
- 卷：14
- 期：10
- 页码：5662-5671
- 全文大小：514K
- ISSN：1530-6992
文摘
Our recent advancements in RNA nanotechnology introduced novel nanoscaffolds (nanorings); however, the potential of their use for biomedical applications was never fully revealed. As presented here, besides functionalization with multiple different short interfering RNAs for combinatorial RNA interference (e.g., against multiple HIV-1 genes), nanorings also allow simultaneous embedment of assorted RNA aptamers, fluorescent dyes, proteins, as well as recently developed RNA鈥揇NA hybrids aimed to conditionally activate multiple split functionalities inside cells.