Quinol-4-ones as Steroid A-Ring Mimetics in Nonsteroidal Dissociated Glucocorticoid Agonists

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• 作者：John Regan ; Thomas W. Lee ; René ; e M. Zindell ; Younes Bekkali ; Jö ; rg Bentzien ; Thomas Gilmore ; Abdelhakim Hammach ; Thomas M. Kirrane ; Alison J. Kukulka ; Daniel Kuzmich ; Richard M. Nelson ; Joh
• 刊名：Journal of Medicinal Chemistry
• 出版年：2006
• 出版时间：December 28, 2006
• 年：2006
• 卷：49
• 期：26
• 页码：7887 - 7896
• 全文大小：149K
• 年卷期：v.49,no.26(December 28, 2006)
• ISSN：1520-4804

文摘

We report on the nuclear receptor binding affinities, cellular activities of transrepression and transactivation,and anti-inflammatory properties of a quinol-4-one and other A-ring mimetic containing nonsteroidal classof glucocorticoid agonists.