Base-Mediated Intramolecular C- and N-Arylation of N,N-Disubstituted 2-Nitrobenzenesulfonamides: Advanced Intermediates for the Synthesis of Diverse Nitrogenous Heterocycles
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- 作者：Petra Smyslov谩 ; Ksenija Kisseljova ; Viktor Krch艌谩k
- 刊名：ACS Combinatorial Science
- 出版年：2014
- 出版时间：September 8, 2014
- 年：2014
- 卷：16
- 期：9
- 页码：500-505
- 全文大小：332K
- ISSN：2156-8944
文摘
Structural and electronic features that facilitate and direct the intramolecular C- and N-arylation of 2-alkyl-2-{[N-(benzyl)-2-nitrophenyl]sulfonamido}acetic acid esters and amides were examined. The substitution pattern and amino acid carboxy-terminal functionality determined the arylation position. C/N-arylated products represent advanced intermediates for combinatorial synthesis of diverse nitrogenous heterocycles, including indazoles, quinazolinones, quinoxalinones, and 3-amino-2-oxindoles.