Highly Enantioselective Dynamic Kinetic Resolution of 1,2-Diarylethanols by a Lipase-Ruthenium Couple

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• 作者：Mahn-Joo Kim ; Yoon Kyung Choi ; Sol Kim ; Daeho Kim ; Kiwon Han ; Soo-Byung Ko ; Jaiwook Park
• 刊名：Organic Letters
• 出版年：2008
• 出版时间：March 20, 2008
• 年：2008
• 卷：10
• 期：6
• 页码：1295 - 1298
• 全文大小：62K
• 年卷期：v.10,no.6(March 20, 2008)
• ISSN：1523-7052

文摘

A practical procedure has been developed for the dynamic kinetic resolution of 1,2-diarylethanols. This procedure employs a highlyenantioselective lipase from Pseudomonas stutzeri (trade name, lipase TL) as the resolution catalyst and a ruthenium complex as the racemizationcatalyst. Sixteen 1,2-diarylethanols have been efficiently resolved to provide their acetyl derivatives with good yields (95-97%) and highenantiomeric excesses (96-99%).