Pyrethroid Pesticide Exposure and Risk of Childhood Acute Lymphocytic Leukemia in Shanghai

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• 作者：Guodong Ding ; Rong Shi ; Yu Gao ; Yan Zhang ; Michihiro Kamijima ; Kiyoshi Sakai ; Guoquan Wang ; Chao Feng ; Ying Tian
• 刊名：Environmental Science & Technology (ES&T)
• 出版年：2012
• 出版时间：December 18, 2012
• 年：2012
• 卷：46
• 期：24
• 页码：13480-13487
• 全文大小：216K
• 年卷期：v.46,no.24(December 18, 2012)
• ISSN：1520-5851

文摘

Significant amounts of pyrethroid pesticides are used throughout China. Previous studies have suggested that exposure to pesticides may increase the risk of childhood cancer; however, few studies have focused on pyrethroid metabolites. We investigated five nonspecific metabolites of pyrethroid pesticides found in children鈥檚 urine and examined the correlation with childhood leukemia. We conducted a hospital-based case-control study of childhood acute lymphocytic leukemia (ALL) in Shanghai between 2010 and 2011. The study included 176 children aged 0鈥?4 years and 180 controls matched for age and sex. Compared with those in the lowest quartiles of total and individual metabolites, the highest quartiles were associated with an approximate 2-fold increased risk of ALL [total metabolites: odds ratio (OR) = 2.75, 95% confidence interval (CI), 1.43鈥?.29; cis-DCCA: OR = 2.21, 95% CI, 1.16鈥?.19; trans-DCCA: OR = 2.33, 95% CI, 1.23鈥?.41; and 3-PBA: OR = 1.84, 95% CI, 1.00鈥?.38], and most of the positive trends were significant (p < 0.05). Our findings suggest that urinary levels of pyrethroid metabolites may be associated with an elevated risk of childhood ALL and represent a previously unreported quantitative exposure assessment for childhood leukemia.