KDR Kinase Inhibitor Isolated from the Mushroom Boletopsis leucomelas

详细信息    查看全文

• 作者：Akira Kaneko ; Mariko Tsukada ; Miyuki Fukai ; Toshihiro Suzuki ; Kazuto Nishio ; Kazuhiko Miki ; Kaoru Kinoshita ; Kunio Takahashi ; Kiyotaka Koyama
• 刊名：Journal of Natural Products
• 出版年：2010
• 出版时间：May 28, 2010
• 年：2010
• 卷：73
• 期：5
• 页码：1002-1004
• 全文大小：101K
• 年卷期：v.73,no.5(May 28, 2010)
• ISSN：1520-6025

文摘

Three novel p-terphenyl compounds, named boletopsins A (1), B (2), and C (3), and four known analogues (4−7) were isolated from fruiting bodies of the mushroom Boletopsis leucomelas. Compounds 1−7 were tested for KDR kinase inhibitory activity, and boletopsin C (3) was found to have an IC₅₀ value of 70.7 μΜ. Compound 3 also showed inhibition of proliferation of human umbilical vein endothelial cells, with an IC₅₀ value of 9.04 μM.