Potential Anti-angiogenesis Effects of p-Terphenyl Compounds from Polyozellus multiplex
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- 作者：Ikuko Nagasawa ; Akira Kaneko ; Toshihiro Suzuki ; Kazuto Nishio ; Kaoru Kinoshita ; Motto Shiro ; Kiyotaka Koyama
- 刊名：Journal of Natural Products
- 出版年：2014
- 出版时间：April 25, 2014
- 年：2014
- 卷：77
- 期：4
- 页码：963-968
- 全文大小：425K
- 年卷期：v.77,no.4(April 25, 2014)
- ISSN：1520-6025
文摘
One novel p-terphenyl compound, polyozellic acid (1), and its acetone adduct (3), along with a known p-terphenyl compound, thelephoric acid (2), were isolated from the mushroom Polyozellus multiplex. Their molecular structures were determined by spectroscopic analysis, X-ray crystallographic analysis, and chemical modification. In some assays related to angiogenesis, compounds 1 and 2 in particular showed inhibitory effects on proliferation, tubule formation, and invasion of human umbilical vein endothelial cells. The quinone moiety within these molecules possibly contributes to their antiangiogenesis activity.