Biosynthesis of Panaefluoroline B from the Cultured Mycobiont of Amygdalaria panaeola

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• 作者：Kaoru Kinoshita ; Mirei Fukumaru ; Yoshikazu Yamamoto ; Kiyotaka Koyama ; Kunio Takahashi
• 刊名：Journal of Natural Products
• 出版年：2015
• 出版时间：July 24, 2015
• 年：2015
• 卷：78
• 期：7
• 页码：1745-1747
• 全文大小：203K
• ISSN：1520-6025

文摘

Panaefluoroline B (2) is a fluorescent yellowish-green pigment produced by the cultured mycobiont of a lichen, Amygdalaria panaeola. Panaefluoroline B (2) has an isoquinoline skeleton, a C₅ unit, and an amino acid, glycine, in its structure. The biosynthetic pathway of 2 was revealed by feeding experiments using [1-¹³C]-sodium acetate and [1,2-¹³C₂][¹⁵N]-glycine. The analysis of labeling patterns of 2 and its mass spectrum suggested the isoquinoline part is biosynthesized via the acetate鈥搈alonate pathway with glycine as the nitrogen source and that the C₅ unit originates from the mevalonate pathway.