Macrolides from a Marine-Derived Fungus, Penicillium meleagrinum var. viridiflavum, Showing Synergistic Effects with Fluconazole against Azole-Resistant Candida albicans
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- 作者：Miki Okabe ; Takashi Sugita ; Kaoru Kinoshita ; Kiyotaka Koyama
- 刊名：Journal of Natural Products
- 出版年：2016
- 出版时间：April 22, 2016
- 年：2016
- 卷：79
- 期：4
- 页码：1208-1212
- 全文大小：250K
- 年卷期：0
- ISSN：1520-6025
文摘
Two new 13-membered macrolides (1, 7), along with known 13-membered macrolides PF1163A, B, D, H, and F (2–6), were isolated from a strain of a marine-derived fungus, Penicillium meleagrinum var. viridiflavum. The structures of 1 and 7 were elucidated from spectroscopic data (NMR, MS, IR). Compounds 1–7 showed synergistic effects with fluconazole against azole-resistant Candida albicans by a checkerboard assay.