Microtermolides A and B from Termite-Associated Streptomyces sp. and Structural Revision of Vinylamycin

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• 作者：Gavin Carr ; Michael Poulsen ; Jonathan L. Klassen ; Yanpeng Hou ; Thomas P. Wyche ; Tim S. Bugni ; Cameron R. Currie ; Jon Clardy
• 刊名：Organic Letters
• 出版年：2012
• 出版时间：June 1, 2012
• 年：2012
• 卷：14
• 期：11
• 页码：2822-2825
• 全文大小：194K
• 年卷期：v.14,no.11(June 1, 2012)
• ISSN：1523-7052

文摘

Microtermolides A (1) and B (2) were isolated from a Streptomyces sp. strain associated with fungus-growing termites. The structures of 1 and 2 were determined by 1D- and 2D-NMR spectroscopy and high-resolution mass spectrometry. Structural elucidation of 1 led to the re-examination of the structure originally proposed for vinylamycin (3). Based on a comparison of predicted and experimental ¹H and ¹³C NMR chemical shifts, we propose that vinylamycin鈥檚 structure be revised from 3 to 4.