Indiacens A and B: Prenyl Indoles from the Myxobacterium Sandaracinus amylolyticus

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• 作者：Heinrich Steinmetz ; Kathrin I. Mohr ; Wiebke Zander ; Rolf Jansen ; Klaus Gerth ; Rolf M眉ller
• 刊名：Journal of Natural Products
• 出版年：2012
• 出版时间：October 26, 2012
• 年：2012
• 卷：75
• 期：10
• 页码：1803-1805
• 全文大小：182K
• 年卷期：v.75,no.10(October 26, 2012)
• ISSN：1520-6025

文摘

The gliding bacterium Sandaracinus amylolyticus, strain NOSO-4T, was recently characterized as the first representative of a new myxobacterial genus. A screening of the culture broth for antibiotically active metabolites followed by isolation and characterization revealed two unique 3-formylindol derivatives, indiacen A (1) and its chloro derivative indiacen B (2). Both are active against Gram-positive and Gram-negative bacteria as well as the fungus Mucor hiemalis. The biosynthetic origin of the isoprene-like side chain in 1 and 2 was studied by in vivo feeding experiments with ¹³C-labeled precursors.