Hyaladione, an S-Methyl Cyclohexadiene-dione from Hyalangium minutum

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• 作者：Patrick W. Okanya ; Kathrin I. Mohr ; Klaus Gerth ; Heinrich Steinmetz ; Volker Huch ; Rolf Jansen ; Rolf M眉ller
• 刊名：Journal of Natural Products
• 出版年：2012
• 出版时间：April 27, 2012
• 年：2012
• 卷：75
• 期：4
• 页码：768-770
• 全文大小：176K
• 年卷期：v.75,no.4(April 27, 2012)
• ISSN：1520-6025

文摘

A bioassay-guided fractionation of the crude methanol extract of the myxobacterium Hyalangium minutum, strain NOCB-2^T (DSM 14724^T), led to the isolation of hyaladione (1), a novel S-methyl cyclohexadiene-dione. The structure of 1 was established by HRESIMS, NMR, and IR spectroscopy as well as X-ray crystallography. Compound 1 was active against growing mammalian cell lines, with IC₅₀ values ranging from 1.23 to 3.93 渭M, in addition to a broad spectrum of antibacterial and antifungal activities, including inhibition of pathogenic methicillin-resistant Staphylococcus aureus and Pseudomonas aeruginosa with an MIC of 0.83 and 8.5 渭g mL^鈥?, respectively.