Synthesis of 2-Aminoazoles from Thioesters via 伪-Heterosubstituted Ketones by Copper-Mediated Cross-Coupling

详细信息    查看全文

• 作者：Hiroyuki Kobayashi ; John A. Eickhoff ; Armen Zakarian
• 刊名：Journal of Organic Chemistry
• 出版年：2015
• 出版时间：October 16, 2015
• 年：2015
• 卷：80
• 期：20
• 页码：9989-9999
• 全文大小：395K
• ISSN：1520-6904

文摘

Facile synthesis of a variety of 伪-heterosubstituted ketones under mild conditions was achieved by copper-mediated cross-coupling of thioesters with functionalized organostannanes. Application of this coupling methodology provided a concise pathway for the conversion of carboxylic acids to 2-aminoimidazoles, 2-aminothiazoles, and 2-aminooxazoles via thioesters in practical yields.