Agelamadins A and B, Dimeric Bromopyrrole Alkaloids from a Marine Sponge Agelas sp.

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• 作者：Taishi Kusama ; Naonobu Tanaka ; Kanae Sakai ; Tohru Gonoi ; Jane Fromont ; Yoshiki Kashiwada ; Jun鈥檌chi Kobayashi
• 刊名：Organic Letters
• 出版年：2014
• 出版时间：August 1, 2014
• 年：2014
• 卷：16
• 期：15
• 页码：3916-3918
• 全文大小：221K
• ISSN：1523-7052

文摘

Two structurally unique dimeric bromopyrrole alkaloids, agelamadins A (1) and B (2), were isolated from a marine sponge Agelas sp. Agelamadins A (1) and B (2) have a structure consisting of an agelastatin-like tetracyclic moiety and an oroidin-like linear moiety in common. The structures of 1 and 2 were elucidated on the basis of spectroscopic analysis. The antimicrobial activity and cytotoxicity of agelamadins A (1) and B (2) were evaluated.