An Efficient Route to Rattle-Type Fe3O4@SiO2 Hollow Mesoporous Spheres Using Colloidal Carbon Spheres Templates

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• 作者：Yufang Zhu ; Emanuel Kockrick ; Toshiyuki Ikoma ; Nobutaka Hanagata ; Stefan Kaskel
• 刊名：Chemistry of Materials
• 出版年：2009
• 出版时间：June 23, 2009
• 年：2009
• 卷：21
• 期：12
• 页码：2547-2553
• 全文大小：380K
• 年卷期：v.21,no.12(June 23, 2009)
• ISSN：1520-5002

文摘

Rattle-type Fe₃O₄@SiO₂ hollow mesoporous spheres with large cavities have been successfully prepared by using the colloidal carbon spheres as the templates. The spheres are well monodisperse and nearly uniform in dimension with particle size of ca. 900 nm. The thickness of the mesoporous silica shell is about 100 nm, and only one Fe₃O₄ particle of ca. 100 nm in diameter is encapsulated in each hollow mesoporous silica sphere. The magnetic measurement indicated that the Fe₃O₄@SiO₂ hollow mesoporous spheres exhibited ferromagnetic behavior with the magnetization saturation of 1.6 emu/g. Using aspirin as a model drug, the Fe₃O₄@SiO₂ hollow mesoporous spheres showed high drug loading capacity and sustained release property. Therefore, this kind of magnetic hollow mesoporous spheres provides a very promising candidate for application in a targeted drug delivery system.