Formation Process of Cyclodextrin Necklace-Analysis of Hydrogen Bonding on a Molecular Level

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• 作者：Koji Miyake ; Satoshi Yasuda ; Akira Harada ; Jun Sumaoka ; Makoto Komiyama ; and Hidemi Shigekawa
• 刊名：Journal of the American Chemical Society
• 出版年：2003
• 出版时间：April 30, 2003
• 年：2003
• 卷：125
• 期：17
• 页码：5080 - 5085
• 全文大小：452K
• 年卷期：v.125,no.17(April 30, 2003)
• ISSN：1520-5126

文摘

By means of scanning tunneling microscopy (STM), we succeeded for the first time in thequantitative analysis of the intramolecular conformation of a supramolecule, cyclodextrin (CyD) necklace,driven by hydrogen bonding. Contrary to the current model, based on macroscopic analyses, which indicatesthat all CyDs are arranged in head-to-head or tail-to-tail (secondary-secondary or primary-primary hydrogenbonding) conformation, about 20% head-to-tail (primary-secondary hydrogen bonding) conformation wasfound to exist in the molecule. In addition, comparing the STM results with the theoretical model of thenecklace formation, the formation ratio of the tail-to-tail and head-to-tail conformations due to the strengthdifference between primary-primary and primary-secondary hydrogen bonds of CyDs was directly obtained,for the first time, to be 2:1.