Biologically Active Acetylenic Amino Alcohol and N-Hydroxylated 1,2,3,4-Tetrahydro-β-carboline Constituents of the New Zealand Ascidian Pseudodistoma opacum
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- 作者：Jiayi Wang ; A. Norrie Pearce ; Susanna T. S. Chan ; Richard B. Taylor ; Michael J. Page ; Alexis Valentin ; Marie-Lise Bourguet-Kondracki ; James P. Dalton ; Siouxsie Wiles ; Brent R. Copp
- 刊名：Journal of Natural Products
- 出版年：2016
- 出版时间：March 25, 2016
- 年：2016
- 卷：79
- 期：3
- 页码：607-610
- 全文大小：224K
- ISSN：1520-6025
文摘
The first occurrence of an acetylenic 1-amino-2-alcohol, distaminolyne A (1), isolated from the New Zealand ascidian Pseudodistoma opacum, is reported. The isolation and structure elucidation of 1 and assignment of absolute configuration using the exciton coupled circular dichroism technique are described. In addition, a new N-9 hydroxy analogue (2) of the known P. opacum metabolite 7-bromohomotrypargine is also reported. Antimicrobial screening identified modest activity of 1 toward Escherichia coli, Staphylococcus aureus, and Mycobacterim tuberculosis, while 2 exhibited a moderate antimalarial activity (IC50 3.82 μM) toward a chloroquine-resistant strain (FcB1) of Plasmodium falciparum.