Active Constituents from Drynaria fortunei Rhizomes on the Attenuation of A尾25鈥?5-Induced Axonal Atrophy

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• 作者：Zhi-You Yang ; Tomoharu Kuboyama ; Kohei Kazuma ; Katsuhiro Konno ; Chihiro Tohda
• 刊名：Journal of Natural Products
• 出版年：2015
• 出版时间：September 25, 2015
• 年：2015
• 卷：78
• 期：9
• 页码：2297-2300
• 全文大小：255K
• ISSN：1520-6025

文摘

Axonal regeneration might contribute to the restoration of damaged neuronal networks and improvement of memory deficits in a murine Alzheimer鈥檚 disease (AD) model. A search for axonal regenerative drugs was performed to discover novel therapeutic options for AD. In this study, an aqueous extract of Drynaria fortunei rhizomes reversed A尾_25鈥?5-induced axonal atrophy in cultured cortical neurons of mice. Bioassay-guided fractionation of this extract led to the isolation and identification of compounds 1鈥?b>5. Among them, (2S)-neoeriocitrin (2) and caffeic acid 4-O-glucoside (4) showed significant axonal elongation effects on A尾_25鈥?5-induced atrophy.