Scale-Up of Microwave-Promoted Reactions to the Multigram Level Using a Sealed-Vessel Microwave Apparatus
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- 作者：Matthew D. Bowman ; Jason R. Schmink ; Cynthia M. McGowan ; Chad M. Kormos ; Nicholas E. Leadbeater
- 刊名：Organic Process Research & Development
- 出版年：2008
- 出版时间：November 21, 2008
- 年：2008
- 卷：12
- 期：6
- 页码：1078-1088
- 全文大小：291K
- 年卷期：v.12,no.6(November 21, 2008)
- ISSN：1520-586X
文摘
A range of synthetic transformations have been scaled up successfully using a sealed-vessel multimode microwave unit. These include metal-catalyzed couplings, synthesis of heterocycles, reactions under an atmosphere of reactive gas and two-step one-pot procedures. Also, observations have been made along the way that are of use to chemists addressing scale-up of microwave-promoted reactions.