Controlled Self-Assembly of Multiple Diastereomeric Macrocyclic Boronic Esters Composed of Two Chiral Units

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• 作者：Suguru Ito ; Kosuke Ono ; Nobuharu Iwasawa
• 刊名：The Journal of the American Chemical Society
• 出版年：2012
• 出版时间：August 29, 2012
• 年：2012
• 卷：134
• 期：34
• 页码：13962-13965
• 全文大小：285K
• 年卷期：v.134,no.34(August 29, 2012)
• ISSN：1520-5126

文摘

Controlled construction of four out of five diastereomers of macrocyclic boronic ester was achieved in high yield by utilizing the self-assembly of two chiral components with the proper choice of reaction conditions. Three diastereomers could be constructed as enantiopure forms by properly changing the chirality combination between the two building blocks. Furthermore, the methodology could be applicable to the three-component self-assembly of enantiopure macrocyclic boronic esters having two different diboronic acid moieties.