Synthesis of Strained Pyridine-Containing Cyclyne via Reductive Aromatization
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- 作者：Koji Miki ; Michiyasu Fujita ; Yuki Inoue ; Yoshinori Senda ; Toshiyuki Kowada ; Kouichi Ohe
- 刊名：Journal of Organic Chemistry
- 出版年：2010
- 出版时间：May 21, 2010
- 年：2010
- 卷：75
- 期：10
- 页码：3537-3540
- 全文大小：788K
- 年卷期：v.75,no.10(May 21, 2010)
- ISSN：1520-6904
文摘
The Sonogashira−Hagihara coupling reactions of 2,6-diiodopyridine and cis-3,6-diethynyl-3,6-dimethoxycyclohexa-1,4-diene or cis-9,10-diethynyl-9,10-dimethoxy-9,10-dihydroanthracene gave macrocyclic compounds having alternating 2,6-diethynylpyridine and 3,6-dimethoxycyclohexa-1,4-diene segments. Transformation of the C3-symmetric 2,6-diethynylpyridine-based cyclotrimer was efficiently achieved using tin-mediated reductive aromatization under mild conditions.