Lignans from Cell Suspension Cultures of Phyllanthus niruri, an Indonesian Medicinal Plant

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• 作者：Elfahmi ; Sieb Batterman ; Albert Koulman ; Thomas Hackl ; Rein Bos ; Oliver Kayser ; Herman J. Woerdenbag ; and Wim J. Quax
• 刊名：Journal of Natural Products
• 出版年：2006
• 出版时间：January 2006
• 年：2006
• 卷：69
• 期：1
• 页码：55 - 58
• 全文大小：60K
• 年卷期：v.69,no.1(January 2006)
• ISSN：1520-6025

文摘

Cell suspension cultures of Phyllanthus niruri were used to study the lignan profiles and biosynthesis. Suspensioncultures yielded two lignans: the new cubebin dimethyl ether (1) and urinatetralin (2), a new lignan from P. niruri, butreported earlier from P. urinaria. This is the first report of cell suspension cultures of P. niruri that successfully producelignans. Feeding 0.5 mM ferulic acid or 0.5 mM caffeic acid, being early precursors of lignan biosynthesis, resulted inan increase up to 0.7 mg g^-1 DW of 1 (control value 0.1 mg g^-1 DW) and up to 0.3 mg g^-1 DW of 2 (control value0.2 mg g^-1 DW). Comparison of the lignan profiles of cell suspensions, callus cultures, aerial plant parts, roots, andseeds showed significant differences.