Supramolecular Architecture in an Oxovanadium(V)-Schiff Base Complex: Synthesis, Ab initio Structure Determination from X-ray Powder Diffraction, DNA Binding and Cleavage Activity
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- 作者：Swastik Mondal ; Monika Mukherjee ; Koushik Dhara ; Soumen Ghosh ; Jagnyeswar Ratha ; Pradyot Banerjee ; Alok K. Mukherjee
- 刊名：Crystal Growth & Design
- 出版年：2007
- 出版时间：September 2007
- 年：2007
- 卷：7
- 期：9
- 页码：1716 - 1721
- 全文大小：246K
- 年卷期：v.7,no.9(September 2007)
- ISSN：1528-7505
文摘
The synthesis, spectroscopic characterization, X-ray powder structure determination, and thermal behavior of a binuclearbis(
-oxo)-bridged vanadium(V) complex, [(VO2L)2], L = N,N'-dimethylenediamine(o-hydroxyl acetophenon), along with its DNAbinding ability and photoinduced DNA cleavage activity, have been described. The compound crystallizes in a monoclinic systemwith a = 7.679(3) Å, b = 12.020(5) Å, c = 13.882(6) Å, 
= 90.799(4)
, space group P21/c, and Z = 2. The crystal structure hasbeen solved from laboratory X-ray powder diffraction data using the direct space approach and refined by the Rietveld method. Thedimeric complex consists of two edge-sharing vanadium octahedra with each metal center coordinated to one oxo-, one phenolate-,and two bridging-oxygen ligands, and two nitrogen donor atoms. The molecular structure reveals a two-dimensional grid of 
(24)rings in the (011) plane, which on combination with one-dimensional polymeric chains along the [100] direction, forms a novelthree-dimensional supramolecular framework. Thermogravimetric analysis of the complex indicates multiple overlapping decompositionsteps in the temperature range 180-800 C with the end product being V2O5. The complex binds to double-stranded DNA givinga Kapp value of 1.56 × 107 M-1 and displays DNA cleavage activity on UV (300 nm) irradiation via a mechanistic pathway involvingformation of singlet oxygen as the reactive species.
-oxo)-bridged vanadium(V) complex, [(VO2L)2], L = N,N'-dimethylenediamine(o-hydroxyl acetophenon), along with its DNAbinding ability and photoinduced DNA cleavage activity, have been described. The compound crystallizes in a monoclinic systemwith a = 7.679(3) Å, b = 12.020(5) Å, c = 13.882(6) Å, = 90.799(4), space group P21/c, and Z = 2. The crystal structure hasbeen solved from laboratory X-ray powder diffraction data using the direct space approach and refined by the Rietveld method. Thedimeric complex consists of two edge-sharing vanadium octahedra with each metal center coordinated to one oxo-, one phenolate-,and two bridging-oxygen ligands, and two nitrogen donor atoms. The molecular structure reveals a two-dimensional grid of (24)rings in the (011) plane, which on combination with one-dimensional polymeric chains along the [100] direction, forms a novelthree-dimensional supramolecular framework. Thermogravimetric analysis of the complex indicates multiple overlapping decompositionsteps in the temperature range 180-800 C with the end product being V2O5. The complex binds to double-stranded DNA givinga Kapp value of 1.56 × 107 M-1 and displays DNA cleavage activity on UV (300 nm) irradiation via a mechanistic pathway involvingformation of singlet oxygen as the reactive species.