Dynamic Peptide Library for the Discovery of Charge Transfer Hydrogels

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• 作者：Cristina Berdugo ; Siva Krishna Mohan Nalluri ; Nadeem Javid ; Beatriu Escuder ; Juan F. Miravet ; Rein V. Ulijn
• 刊名：ACS Applied Materials & Interfaces
• 出版年：2015
• 出版时间：November 25, 2015
• 年：2015
• 卷：7
• 期：46
• 页码：25946-25954
• 全文大小：596K
• ISSN：1944-8252

文摘

Coupling of peptide self-assembly to dynamic sequence exchange provides a useful approach for the discovery of self-assembling materials. In here, we demonstrate the discovery and optimization of aqueous, gel-phase nanostructures based on dynamically exchanging peptide sequences that self-select to maximize charge transfer of n-type semiconducting naphthalenediimide (NDI)-dipeptide bioconjugates with various 蟺-electron-rich donors (dialkoxy/hydroxy/amino-naphthalene or pyrene derivatives). These gel-phase peptide libraries are characterized by spectroscopy (UV鈥搗is and fluorescence), microscopy (TEM), HPLC, and oscillatory rheology and it is found that, of the various peptide sequences explored (tyrosine Y-NDI with tyrosine Y, phenylalanine F, leucine L, valine V, alanine A or glycine G-NH₂), the optimum sequence is tyrosine-phenylalanine in each case; however, both its absolute and relative yield amplification is dictated by the properties of the donor component, indicating cooperativity of peptide sequence and donor/acceptor pairs in assembly. The methodology provides an in situ discovery tool for nanostructures that enable dynamic interfacing of supramolecular electronics with aqueous (biological) systems.