Synthesis and Characterization of Thermally and Chemically Gelling Injectable Hydrogels for Tissue Engineering

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• 作者：Adam K. Ekenseair ; Kristel W. M. Boere ; Stephanie N. Tzouanas ; Tiffany N. Vo ; F. Kurtis Kasper ; Antonios G. Mikos
• 刊名：Biomacromolecules
• 出版年：2012
• 出版时间：June 11, 2012
• 年：2012
• 卷：13
• 期：6
• 页码：1908-1915
• 全文大小：451K
• 年卷期：v.13,no.6(June 11, 2012)
• ISSN：1526-4602

文摘

Novel, injectable hydrogels were developed that solidify through a physical and chemical dual-gelation mechanism upon preparation and elevation of temperature to 37 掳C. A thermogelling, poly(N-isopropylacrylamide)-based macromer with pendant epoxy rings and a hydrolytically degradable polyamidoamine-based diamine cross-linker were synthesized, characterized, and combined to produce in situ forming hydrogel constructs. Network formation through the epoxy-amine reaction was shown to be rapid and facile, and the progressive incorporation of the hydrophilic polyamidoamine cross-linker into the hydrogel was shown to mitigate the often problematic tendency of thermogelling materials to undergo significant postformation gel syneresis. The results suggest that this novel class of injectable hydrogels may be attractive substrates for tissue engineering applications due to the synthetic versatility of the component materials and beneficial hydrogel gelation kinetics and stability.