Efficient, Regioselective Palladium-Catalyzed Tandem Heck-Isomerization Reaction of Aryl Bromides and Non-Allylic Benzyl Alcohols
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- 作者：Matthew L. Crawley*† ; ; Kristin M. Phipps† ; ; Igor Goljer‡ ; ; John F. Mehlmann† ; ; Joseph T. Lundquist† ; ; John W. Ullrich
- 刊名：Organic Letters
- 出版年：2009
- 出版时间：March 5, 2009
- 年：2009
- 卷：11
- 期：5
- 页码：1183-1185
- 全文大小：116K
- 年卷期：v.11,no.5(March 5, 2009)
- ISSN：1523-7052
文摘
An efficient and mild method to couple aryl bromides and activated non-allylic alcohols in a Heck reaction with tandem isomerization to selectively afford high yields of 1,5-diarylalkan-1-ones has been developed. Mechanistic insight was gained through NMR studies of products derived from deuterium-labeled intermediates.