Analogues of the Epoxy Resin Monomer Diglycidyl Ether of Bisphenol F: Effects on Contact Allergenic Potency and Cytotoxicity

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• 作者：Niamh M. O'Boyle ; Tamara Delaine ; Kristina Luthman ; Andreas Natsch ; Ann-Therese Karlberg
• 刊名：Chemical Research in Toxicology
• 出版年：2012
• 出版时间：November 19, 2012
• 年：2012
• 卷：25
• 期：11
• 页码：2469-2478
• 全文大小：345K
• 年卷期：v.25,no.11(November 19, 2012)
• ISSN：1520-5010

文摘

Diglycidyl ethers of bisphenol A (DGEBA) and bisphenol F (DGEBF) are widely used as components in epoxy resin thermosetting products. They are known to cause occupational and nonoccupational allergic contact dermatitis. The aim of this study is to investigate analogues of DGEBF with regard to contact allergy and cytotoxicity. A comprehensive knowledge of the structural features that contribute to the allergenic and cytotoxic effects of DGEBF will guide the development of future novel epoxy resin systems with reduced health hazards for those coming into contact with them. It was found that the allergenic effects of DGEBF were dependent on its terminal epoxide groups. In contrast, it was found that the cytotoxicity in monolayer cell culture was dependent not only on the presence of epoxide groups but also on other structural features.