Tortuosenes A and B, New Diterpenoid Metabolites from the Formosan Soft Coral Sarcophyton tortuosum

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• 作者：Kuan-Hua Lin ; Yen-Ju Tseng ; Bo-Wei Chen ; Tsong-Long Hwang ; Hsing-Yin Chen ; Chang-Feng Dai ; Jyh-Horng Sheu
• 刊名：Organic Letters
• 出版年：2014
• 出版时间：March 7, 2014
• 年：2014
• 卷：16
• 期：5
• 页码：1314-1317
• 全文大小：261K
• 年卷期：v.16,no.5(March 7, 2014)
• ISSN：1523-7052

文摘

Tortuosenes A and B (1 and 2), possessing new diterpenoid molecular structures, were isolated from the Formosan soft coral Sarcophyton tortuosum along with a known cembrane, emblide (3). The structures of 1 and 2 were established by extensive spectroscopic analysis, and the absolute configuration of 1 was determined by TDDFT ECD calculations. Tortuosene A was found to display significant inhibitory effects on the generation of the superoxide anion in N-formyl-methionyl-leucyl-phenylalanine/cytochalasin B (fMLP/CB)-induced neutrophils.