Catalytic Asymmetric Conjugate Allylation of Coumarins

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• 作者：Yulong Kuang ; Xiaohua Liu ; Lu Chang ; Min Wang ; Lili Lin ; Xiaoming Feng
• 刊名：Organic Letters
• 出版年：2011
• 出版时间：August 5, 2011
• 年：2011
• 卷：13
• 期：15
• 页码：3814-3817
• 全文大小：769K
• 年卷期：v.13,no.15(August 5, 2011)
• ISSN：1523-7052

文摘

A catalytic asymmetric conjugate allylation was successfully developed to synthesize potential pharmacologically active 4-allyl-2-oxochroman skeletons. A dual activation strategy was employed by using N,N鈥?dioxide-Yb(OTf)₃ to activate coumarins and using (CuOTf)₂鈥₇H₈ to activate tetraallyltin via transmetalation, respectively. Good yields and enantioselectivities were obtained under mild conditions.