Copper(II)-Mediated Intermolecular C(sp2)–H Amination of Benzamides with Electron-Rich Anilines
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- 作者：Bijaya Kumar Singh ; Arghya Polley ; Ranjan Jana
- 刊名：Journal of Organic Chemistry
- 出版年：2016
- 出版时间：May 20, 2016
- 年：2016
- 卷：81
- 期：10
- 页码：4295-4303
- 全文大小：486K
- 年卷期：0
- ISSN：1520-6904
文摘
Despite significant progress, copper-catalyzed/mediated C–H amination reactions with electron-rich anilines remain an unsolved problem due to catalyst deactivation and deleterious side reactions. Herein, we report a copper(II)-mediated C(sp2)–H amination of benzamides with electronically neutral or electron-rich anilines. A dramatic influence of silver(I) and tetrabutylammonium bromide was observed on the reaction outcome. The present protocol also demonstrates the synthesis of a number of nonsteroidal anti-inflammatory drugs.