Antirestenosis Effect of Butein in the Neointima Formation Progression
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- 作者：Yen-Nien Chen ; Tur-Fu Huang ; Chien-Hsin Chang ; Chun-Chieh Hsu ; Kung- Tin Lin ; Shih-Wei Wang ; Hui-Chin Peng ; Ching-Hu Chung
- 刊名：Journal of Agricultural and Food Chemistry
- 出版年：2012
- 出版时间：July 11, 2012
- 年：2012
- 卷：60
- 期：27
- 页码：6832-6838
- 全文大小：406K
- 年卷期：v.60,no.27(July 11, 2012)
- ISSN：1520-5118
文摘
The development of restenosis involves migration and hyperproliferation of vascular smooth muscle cells (VSMCs). Platelet-derived growth factor (PDGF) is one of the major factors. Butein modulates inflammatory pathways and affects the proliferation and invasion of the tumor. We investigated the hypothesis that butein might prevent the restenosis process via a similar pathway. Our results demonstrated that butein inhibited PDGF-induced VSMC proliferation and migration as determined by BrdU proliferation and two-dimensional migration scratch assay. Butein also concentration-dependently repressed PDGF-induced phosphorylation of PDGF-receptor 尾, mitogen-activated protein kinases, phosphoinositide 3-kinase/Akt, and phopholipase C纬/c-Src in VSMCs. In addition, in vivo results showed that butein attenuated neointima formation in balloon-injured rat carotid arteries. These results indicate that butein may inhibit PDGF-induced VSMC proliferation and migration, resulting in attenuation of neointima formation after percutaneous transluminal coronary angioplasty. Our study demonstrates for the first time that systemic administration of butein is able to reduce neointima formation after vascular injury.