Study on the Antiinflammatory Activity of Essential Oil from Leaves of Cinnamomum osmophloeum
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- 作者：Louis Kuoping Chao ; Kuo-Feng Hua ; Hsien-Yeh Hsu ; Sen-Sung Cheng ; Ju-Yun Liu ; and Shang-Tzen Chang
- 刊名：Journal of Agricultural and Food Chemistry
- 出版年：2005
- 出版时间：September 7, 2005
- 年：2005
- 卷：53
- 期：18
- 页码：7274 - 7278
- 全文大小：82K
- 年卷期：v.53,no.18(September 7, 2005)
- ISSN：1520-5118
文摘
The leaf essential oil from indigenous cinnamon (Cinnamomum osmophloeum Kaneh.) wasinvestigated by gas chromatography-mass spectrometry, and 21 compounds were identified. Themajor constituents of leaf essential oil were the monoterpenes 1,8-cineole (17.0%) and santolinatriene (14.2%) and the sesquiterpenes spathulenol (15.7%) and caryophyllene oxide (11.2%). In theantiinflammatory activity assay, we demonstrated that the essential oil has a higher capacity to inhibitproIL-1
protein expression induced by LPS-treated J774A.1 murine macrophage. At dosages of 60
g/mL, essential oil clearly inhibited proIL-1 protein expression. Furthermore, a dose of 60 g/mLof essential oil was effectively inhibitory for IL-1 and IL-6 production but not for TNF-
, suggestingthat essential oil was bioactive in antiinflammation in vitro. This study is the first to reportantiinflammatory activity of extracts obtained from the leaf essential oil of C. osmophloeum.Keywords: Cinnamomum osmophloeum; leaf; essential oils; GC-MS; antiinflammatory activity;cytokines; macrophages
protein expression induced by LPS-treated J774A.1 murine macrophage. At dosages of 60g/mL, essential oil clearly inhibited proIL-1 protein expression. Furthermore, a dose of 60 g/mLof essential oil was effectively inhibitory for IL-1 and IL-6 production but not for TNF-, suggestingthat essential oil was bioactive in antiinflammation in vitro. This study is the first to reportantiinflammatory activity of extracts obtained from the leaf essential oil of C. osmophloeum.Keywords: Cinnamomum osmophloeum; leaf; essential oils; GC-MS; antiinflammatory activity;cytokines; macrophages