The leaf essential oil from indigenous cinnamon (
Cinnamomum osmophloeum Kaneh.) wasinvestigated by gas chromatography-mass spectrometry, and 21 compounds were identified. Themajor constituents of leaf essential oil were the monoterpenes 1,8-cineole (17.0%) and santolinatriene (14.2%) and the sesquiterpenes spathulenol (15.7%) and caryophyllene oxide (11.2%). In theantiinflammatory activity assay, we demonstrated that the essential oil has a higher capacity to inhibitproIL-1
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protein expression induced by LPS-treated J774A.1 murine macrophage. At dosages of 60
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g/mL, essential oil clearly inhibited proIL-1
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protein expression. Furthermore, a dose of 60
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g/mLof essential oil was effectively inhibitory for IL-1
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and IL-6 production but not for TNF-
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, suggestingthat essential oil was bioactive in antiinflammation in vitro. This study is the first to reportantiinflammatory activity of extracts obtained from the leaf essential oil of
C.
osmophloeum.Keywords:
Cinnamomum osmophloeum; leaf; essential oils; GC-MS; antiinflammatory activity;cytokines; macrophages