General and Practical One-Pot Synthesis of Dihydrobenzosiloles from Styrenes

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• 作者：Alexey Kuznetsov ; Vladimir Gevorgyan
• 刊名：Organic Letters
• 出版年：2012
• 出版时间：February 3, 2012
• 年：2012
• 卷：14
• 期：3
• 页码：914-917
• 全文大小：765K
• 年卷期：v.14,no.3(February 3, 2012)
• ISSN：1523-7052

文摘

A one-pot synthesis of dihydrobenzosiloles from styrenes has been developed. The reaction involves the nickel-catalyzed hydrosilylation of styrene with diphenylsilane, followed by the iridium-catalyzed dehydrogenative cyclization. This method is efficient for both electron-rich and -deficient styrenes and exhibits good functional group tolerance, as well as excellent regioselectivity. The forming dihydrobenzosiloles can be efficiently converted into valuable benzosiloles or 2-hydroxyphenethyl alcohols.