Identification of Antiadipogenic Constituents of the Rhizomes of Anemarrhena asphodeloides

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• 作者：Ui Joung Youn ; Ye Seul Lee ; Hana Jeong ; Jun Lee ; Joo-Won Nam ; Yoo Jin Lee ; Eun Sook Hwang ; Je-Hyun Lee ; Dongho Lee ; Sam Sik Kang ; Eun-Kyoung Seo
• 刊名：Journal of Natural Products
• 出版年：2009
• 出版时间：October 23, 2009
• 年：2009
• 卷：72
• 期：10
• 页码：1895-1898
• 全文大小：138K
• 年卷期：v.72,no.10(October 23, 2009)
• ISSN：1520-6025

文摘

Three new phenolic compounds, (E)-4′-demethyl-6-methyleucomin (1), anemarcoumarin A (2), and anemarchalconyn (3), were isolated from an ethyl acetate extract of the rhizomes of Anemarrhena asphodeloides, together with seven known compounds (4−10). The structures of the new compounds (1−3) were determined on the basis of spectroscopic data interpretation. Compound 3 exhibited a potent inhibitory effect against the differentiation of preadipocyte 3T3-L1 cells with an IC₅₀ value of 5.3 μM.