Asymmetric Synthesis of trans-2,3-Disubstituted Indoline Derivatives

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• 作者：Kyoung Hee Kang ; Junghwan Do ; Yong Sun Park
• 刊名：The Journal of Organic Chemistry
• 出版年：2012
• 出版时间：January 6, 2012
• 年：2012
• 卷：77
• 期：1
• 页码：808-812
• 全文大小：277K
• 年卷期：v.77,no.1(January 6, 2012)
• ISSN：1520-6904

文摘

A novel method for asymmetric synthesis of trans-2,3-disubstituted indolines has been developed. The strategy involves the (鈭?-sparteine-mediated electrophilic substitution of 2-benzyl N-pivaloylaniline with aromatic or 伪,尾-unsaturated aldehydes and subsequent intramolecular nucleophilic substitution. The simple protocol for two-step process can produce highly enantioenriched indolines 3a鈥?b>o up to 98:2 er.