Tripartilactam, a Cyclobutane-Bearing Tricyclic Lactam from a Streptomyces sp. in a Dung Beetle鈥檚 Brood Ball

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• 作者：Seon-Hui Park ; Kyuho Moon ; Hea-Son Bang ; Seong-Hwan Kim ; Dong-Gyu Kim ; Ki-Bong Oh ; Jongheon Shin ; Dong-Chan Oh
• 刊名：Organic Letters
• 出版年：2012
• 出版时间：March 2, 2012
• 年：2012
• 卷：14
• 期：5
• 页码：1258-1261
• 全文大小：231K
• 年卷期：v.14,no.5(March 2, 2012)
• ISSN：1523-7052

文摘

Tripartilactam, a structurally unprecedented cyclobutane-bearing tricyclic lactam metabolite, was discovered from Streptomyces sp. isolated from a brood ball of the dung beetle, Copris tripartitus. The structure of this compound was elucidated by the combination of NMR, MS, UV, and IR spectroscopy and multistep chemical derivatization. Tripartilactam was evaluated as a Na⁺/K⁺ ATPase inhibitor (IC₅₀ = 16.6 渭g/mL).