Ground-State Elevation Approach To Suppress Side Reactions in Gold-Sensing Systems Based on Alkyne Activation

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• 作者：Hyewon Seo ; Mi Eun Jun ; Koteeswari Ranganathan ; Kyung-Ha Lee ; Kyong-Tai Kim ; Woocherl Lim ; Young Min Rhee ; Kyo Han Ahn
• 刊名：Organic Letters
• 出版年：2014
• 出版时间：March 7, 2014
• 年：2014
• 卷：16
• 期：5
• 页码：1374-1377
• 全文大小：254K
• 年卷期：v.16,no.5(March 7, 2014)
• ISSN：1523-7052

文摘

A novel approach to suppress the side reactions observed in the reaction-based gold-sensing systems based on the alkyne activation is disclosed. By elevating steric strain around the reaction site, the gold ion promoted ring-opening process in rhodamine-lactam probes is significantly accelerated, which also leads to suppression of those possible side reactions. As a result, the probes show very high sensitivity in addition to excellent selectivity toward gold species. Furthermore, bioimaging of gold species in live cells was demonstrated with a FRET version.