Potential Lead for an Alzheimer Drug: A Peptide That Blocks Intermolecular Interaction and Amyloid Protein-Induced C
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- 作者：Ju-Won Kwak ; Hyun-Kyung Kim ; Chi-Bom Chae
- 刊名：Journal of Medicinal Chemistry
- 出版年：2006
- 出版时间：August 10, 2006
- 年：2006
- 卷：49
- 期：16
- 页码：4813 - 4817
- 全文大小：189K
- 年卷期：v.49,no.16(August 10, 2006)
- ISSN：1520-4804
文摘
A peptide chA
30-16 (15-mer; CTFVRTHIFCKEHQF) was designed to bind to a region encompassingthe entire polymerization-related (16KLVFF20) and part of the polymerization and toxicity-related (25GSNKGAIIGLM35) regions of amyloid -protein, A1-42 by a hydropathic complementary approach. Thispeptide efficiently binds to A and blocks intermolecular interaction and the formation of A aggregates.In addition, the peptide neutralizes the cell toxicity of A fibrils. The chA30-16 peptide or its derivativesmay be a starting point for the future development of drugs that prevent the neurotoxicity and deposition ofA in the brain of Alzheimer's disease.
30-16 (15-mer; CTFVRTHIFCKEHQF) was designed to bind to a region encompassingthe entire polymerization-related (16KLVFF20) and part of the polymerization and toxicity-related (25GSNKGAIIGLM35) regions of amyloid -protein, A1-42 by a hydropathic complementary approach. Thispeptide efficiently binds to A and blocks intermolecular interaction and the formation of A aggregates.In addition, the peptide neutralizes the cell toxicity of A fibrils. The chA30-16 peptide or its derivativesmay be a starting point for the future development of drugs that prevent the neurotoxicity and deposition ofA in the brain of Alzheimer's disease.