A Facile Access to 4-Substituted-2-naphthols via a Tandem Friedel鈥揅rafts Reaction: A 尾-Chlorovinyl Ketone Pathway

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• 作者：Hun Young Kim ; Kyungsoo Oh
• 刊名：Organic Letters
• 出版年：2014
• 出版时间：November 21, 2014
• 年：2014
• 卷：16
• 期：22
• 页码：5934-5936
• 全文大小：274K
• ISSN：1523-7052

文摘

A one-pot synthesis of 2-naphthol derivatives is accomplished using a tandem Friedel鈥揅rafts reaction sequence. The developed methodology allows for a concomitant construction of up to three C鈥揅 bonds between readily available alkynes and phenylacetyl chloride derivatives by an intermolecular Friedel鈥揅rafts acylation of alkynes followed by an intramolecular Friedel鈥揅rafts alkylation of 尾-chlorovinyl ketone intermediates.