Non-Brownian Diffusion of Membrane Molecules in Nanopatterned Supported Lipid Bilayers
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- 作者：Jones Tsai ; Eileen Sun ; Yuan Gao ; James C. Hone ; Lance C. Kam
- 刊名：Nano Letters
- 出版年：2008
- 出版时间：February 2008
- 年：2008
- 卷：8
- 期：2
- 页码：425 - 430
- 全文大小：251K
- 年卷期：v.8,no.2(February 2008)
- ISSN：1530-6992
文摘
Molecules associated with the outer surface of living cells exhibit complex, non-Brownian patterns of diffusion. In this report, supported lipidbilayers were patterned with nanoscale barriers to capture key aspects of this anomalous diffusion in a controllable format. First, long-rangediffusion coefficients of membrane-associated molecules were significantly reduced by the presence of the barriers, while short-range diffusionwas unaffected. Second, this modulation was more pronounced for large molecular complexes than for individual lipids. Surprisingly, thequantitative effect of these barriers on long-range lipid diffusion could be accurately simulated using a simple, continuum-based model ofdiffusion on a nanostructured surface; we thus describe a metamaterial that captures the properties of the outer membrane of living cells.