Development of a Scalable Synthesis of Gastrazole (JB95008): A Potent CCK2 Receptor Antagonist
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- 作者：Dominic Ormerod ; Bert Willemsens ; Rit Mermans ; Jaak Langens ; Guy Winderickx ; S. Barret Kalindjian ; Ildiko M. Buck ; and Iain M. McDonald
- 刊名：Organic Process Research & Development
- 出版年：2005
- 出版时间：July 2005
- 年：2005
- 卷：9
- 期：4
- 页码：499 - 507
- 全文大小：142K
- 年卷期：v.9,no.4(July 2005)
- ISSN：1520-586X
文摘
A practical and scalable synthesis was developed that was usedto prepare multikilogram batches of gastrazole, a selectivecholecystokinin-2 receptor antagonist. In addition, evidence wasfound to indicate an amide bond-forming reaction proceededvia the isoimide of a benzimidazoleamide acid derivative.