Synthesis of Eukaryotic Translation Elongation Inhibitor Lactimidomycin via Zn(II)-Mediated Horner鈥揥adsworth鈥揈mmons Macrocyclization

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• 作者：Brian J. Larsen ; Zhankui Sun ; Pavel Nagorny
• 刊名：Organic Letters
• 出版年：2013
• 出版时间：June 21, 2013
• 年：2013
• 卷：15
• 期：12
• 页码：2998-3001
• 全文大小：251K
• 年卷期：v.15,no.12(June 21, 2013)
• ISSN：1523-7052

文摘

An enantioselective synthesis of potent eukaryotic translation elongation inhibitor lactimidomycin has been accomplished in 21 linear steps. This synthesis features a Zn(II)-mediated Horner鈥揥adsworth鈥揈mmons reaction that could be executed on a large scale to provide the highly strained 12-membered lactimidomycin macrolactone.